The expermental findings on the inhibition of matrix
metalloprotease activity by TenderWet strongly support the clinical
observation of a fast and efficient induction of granulation tissue.
In summary:
- Excessive levels of matrix metalloproteases (MMPs) interfere with wound healing
- Many to most chronic wounds MMPs show excessive MMP levels (30-fold induced)
- TenderWet binds and inhibits MMPs
- This mechanism is mediated by
- direct binding of the MMPs to the polyacrylate superabsorber (“locked-up”)
- a long range effect which inhibits MMP activity (“non-functional enzyme”)
As
a consequence the wound can recover from the “MMP stress”
and the balance of tissue degradation and build-up is shifted towards
build-up
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