In
the first series of experiments TenderWet – more precisely
the polyacrylate superabsorber particles in TenderWet –
strongly inhibit MMP activity. We used a global assay
(fluorescent peptide clevage) to measure total MMP-2 and MMP-9 activity
levels.
Wound
fluid was incubated with the polyacrylate superabsorber and the amount
of cleaved peptide (which correlates to metalloprotease activity) was
measured.
When
compared with the untreated wound fluid from the same patient (=100%)
there was a strong reduction. This experiment indicates that only a
tiny fraction of the initial MMP activity is left.
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Click on image to enlarge
TenderWet superabsorber (SAP) strongly reduces matrix metalloprotease activity in wound fluid from chronic wounds
TenderWet superabsorber particles are very effective in
reducing MMP activity in chronic wound fluid. They reduce MMP activity
to 13% of the initial values.
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